How long does it take to work?
Sildenafil takes approximately one hour to start working and should be taken about 30 to 60 minutes before you plan to have sex.
How long does it last?
Sildenafil remains active in the body as an effective erectile dysfunction treatment for 3 to 5 hours after it’s taken
For a complete list of moderate to severe side effects when taking Sildenafil, click here.
Can Sildenafil cause permanent effects?
No. The the active amount of Sildenafil in your bloodstream will reduce by approximately half with every four hours. When you get to a certain point, Sildenafil will no longer be present and produce no effects on your body.
Moderate side effects:
- Upset stomach
- Trouble sleeping
- Nose bleed
- Muscle aches
- Stuffy nose
Sildenafil can cause serious side effects. Rarely reported side effects include:
- an erection that will not go away. If you have an erection that lasts more than 4 hours, get medical help right away.
- decreased eyesight or loss of sight in one or both eyes (NAION). If you notice a sudden decrease or loss of eyesight, talk to your healthcare provider right away.
- sudden hearing decrease or hearing loss. Some people may also have ringing in their ears (tinnitus) or dizziness. If you have these symptoms, stop taking Sildenafil and contact your healthcare provider right away
- more shortness of breath than usual. Tell your healthcare provider if you get more short of breath after you start Sildenafil. More shortness of breath than usual may be due to your underlying medical condition.
- low blood pressure. Low blood pressure may cause you to feel faint or dizzy. Lie down if you feel faint or dizzy.
- heart attack, stroke, irregular heartbeats, and death. Most of these happened in men who already had heart problems.
These are not all the possible side effects of Sildenafil.
Tell your doctor if you have any side effect that bothers you or doesn’t go away.
Do not take Sildenafil (sildenafil citrate) if you:
- take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas (riociguat) for pulmonary hypertension. Your blood pressure could drop to an unsafe level
- are allergic to Sildenafil, as contained in Sildenafil and REVATIO, or any of the ingredients in Sildenafil
- You’ve ever had blockage of veins in your lungs, which is called pulmonary veno-occlusive disease
- Are a women or a child
Discuss your health with your doctor to ensure that you are healthy enough for sex.
If you experience chest pain, dizziness, or nausea during sex, seek immediate medical help
Before you take Sildenafil, tell your healthcare provider if you:
- have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain, narrowing of the aortic valve, or heart failure
- have had heart surgery within the last 6 months
- have pulmonary hypertension
- have had a stroke
- have low blood pressure, or high blood pressure that is not controlled
- have a deformed penis shape
- have had an erection that lasted for more than 4 hours
- have problems with your blood cells such as sickle call anemia, multiple myeloma, or leukemia
- have retinitis pigmentosa, a rare genetic (runs in families) eye disease
- have ever had severe vision loss, including an eye problem called NAION
- have bleeding problems
- have or have had stomach ulcers
- have liver problems
- have kidney problems or are having kidney dialysis
- have any other medical conditions
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Sildenafil may affect the way other medicines work, and other medicines may affect the way Sildenafil works, causing side effects.
Especially tell your healthcare provider if you take any of the following:
- medicines called nitrates
- medicines called guanylate cyclase stimulators such as Adempas (riociguat)
- medicines called alpha-blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosinmesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of Sildenafil with alpha-blockers can lead to a drop in blood pressure or to fainting
- medicines called HIV protease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase), or atazanavir sulfate (Reyataz)
- some types of oral antifungal medicines, such as ketoconazole (Nizoral) and itraconazole (Sporanox)
- some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin
- other medicines that treat high blood pressure
- other medicines or treatments for ED
- Sildenafil contains Sildenafil, which is the same medicine found in another drug called REVATIO. REVATIO is used to treat a rare disease called pulmonary arterial hypertension (PAH). Sildenafil should not be used with REVATIO or with other PAH treatments containing Sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil])
Withholding or providing inaccurate information about your health and medical history in order to obtain treatment may result in harm, including, in some cases, death.
Sildenafil does not protect against sexually transmitted diseases, including HIV.