Sertraline

Sertraline is the active ingredient in Zoloft

Sertraline has been shown in clinical practice to be effective in helping men delay orgasm and ejaculation.

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General Info
Side Effects
Safety Information

How does Sertraline work?

Presently, there aren’t any medications specifically approved by the FDA to treat PE.  

However, SSRIs like Sertraline have been shown in clinical practice to be effective in helping men delay orgasm and ejaculation. 

SSRIs are prescription medication, meaning you’ll need to speak with a physician about this PE treatment method.   Physicians are generally permitted to prescribe a drug for an “off label” or “unapproved” use when they determine it is medically appropriate for their patient.

The most common side effects in men treated with Sertraline include:

  • Nausea, loss of appetite, diarrhea, or indigestion
  • Increased sweating
  • Tremor or shaking
  • Agitation
  • Change in sleep habits including increased sleepiness or insomnia
  • Sexual problems including decreased libido and ejaculation failure
  • Feeling tired or fatigued
  • Anxiety

The information below includes important safety information about Sertraline, which is the generic version of the brand name drug Zoloft®. Read this information before you begin taking Sertraline. You must notify your doctor if you start or stop taking Sertraline.

WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS Sertraline and other antidepressant medicines may increase suicidal thoughts or actions, especially in some people 24 years of age and younger within the first few months of treatment or when the dose is changed. Watch for these changes and call your doctor right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Pay particular attention to such changes when Sertraline is started or when the dose is changed.

Do not take Sertraline if you:

  • Are allergic to Sertraline or any of the inactive ingredients in Sertraline.
  • Take a Monoamine Oxidase Inhibitor (MAOI), including linezolid or methylene blue, or if you stopped taking an MAOI in the last 2 weeks. Do not take an MAOI within 2 weeks of stopping Sertraline. Ask your doctor or pharmacist if you are not sure if your medicine is an MAOI.
  • Take Orap® (pimozide) because this can cause serious heart problems.
  • Take Antabuse® (disulfiram) (if you are taking the liquid form of Sertraline) due to the alcohol content of the liquid form of Sertraline.

Call a doctor right away if you or a person you know who is taking Sertraline has any of the following symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide
  • Acting aggressive or violent
  • New or worse depression
  • Feeling agitated, restless, angry, or irritable
  • An increase in activity or talking more than what is normal for you
  • Acting on dangerous impulses
  • Thoughts about suicide or dying
  • New or worse anxiety or panic attacks
  • Trouble sleeping
  • Other unusual changes in behavior or mood

Before taking Sertraline, tell your doctor and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take including; those to treat migraines, psychiatric disorders (including other antidepressants or amphetamines) to avoid a potentially life-threatening condition called Serotonin Syndrome; aspirin, other NSAID pain relievers, or other blood thinners because they may increase the risk of bleeding.

Tell your doctor immediately if you:

  • Become severely ill and have some or all of these symptoms: agitation, hallucinations, coma, or other changes in mental status; coordination problems or muscle twitching (overactive reflexes); racing heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting, or diarrhea; muscle tightness, as these may be the symptoms of a life-threatening condition called Serotonin Syndrome
  • Have a rash, hives, swelling, or trouble breathing as these may be the symptoms of an allergic reaction
  • Have seizures or convulsions
  • Have any increased or unusual bruising or bleeding, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin
  • Have a headache; weakness or feeling unsteady; confusion, problems concentrating, thinking, or remembering, as these may be the symptoms of low salt (sodium) levels in the blood (hyponatremia). Elderly people may be at greater risk for this

Do not stop daily Sertraline without first talking to your healthcare provider. Stopping Sertraline may cause serious symptoms, including anxiety, irritability, high or low mood, feeling restless or sleepy; headache, sweating, nausea, dizziness; electric shock-like sensations, shaking, and confusion.

Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. You may want to undergo an eye examination to see if you are at risk and get preventative treatment if you are.

Sertraline can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how Sertraline affects you.

Drinking alcohol while taking Sertraline is not recommended.

The most common side effects in adults treated with Sertraline include:

  • Nausea, loss of appetite, diarrhea, or indigestion
  • Increased sweating
  • Tremor or shaking
  • Agitation
  • Change in sleep habits including increased sleepiness or insomnia
  • Sexual problems including decreased libido and ejaculation failure
  • Feeling tired or fatigued
  • Anxiety

These are not all the possible side effects of Sertraline.

Tell your doctor if you have any side effect that bothers you or doesn’t go away.